Vol. 3, Issue 1, Part A (2026)

Rasashastra, a branch of Ayurveda, deals with the preparation and utilization of metal-based medicinal compounds. These formulations have been integral to Ayurvedic therapeutics for centuries, known for their unique ability to balance the body's Doshas and treat various diseases. Despite skepticism regarding the safety and efficacy of metal-based formulations, recent advancements in modern medicine and pharmacology have brought renewed interest to the potential therapeutic applications of these ancient remedies. This review explores the scientific rationale behind Rasashastra in contemporary medicine, focusing on the efficacy, safety, and mechanisms of metal-based Ayurvedic formulations. The use of metals such as mercury, lead, and gold in medicinal formulations, under controlled conditions, has demonstrated promising results in treating chronic ailments like rheumatoid arthritis, diabetes, and neurodegenerative disorders. The article discusses the importance of proper detoxification and purification processes involved in Rasashastra to ensure the safety and therapeutic benefits of these metals. Modern techniques, including analytical methods such as atomic absorption spectroscopy and high-performance liquid chromatography, are now used to evaluate the composition and potency of these formulations. Furthermore, this review highlights the challenges and future perspectives of integrating metal-based Ayurvedic formulations into contemporary healthcare systems, including standardization, quality control, and regulatory aspects. By bridging traditional knowledge with modern scientific research, Rasashastra offers a valuable contribution to the development of novel therapeutic strategies that can complement existing medical treatments. The hypothesis of this research posits that metal-based Ayurvedic formulations, when prepared following traditional methods and modernized with scientific validation, can provide significant benefits in modern medicine.