Vol. 3, Issue 1, Part A (2026)

Panchakarma is a set of five therapeutic treatments in Ayurveda, designed for deep detoxification and rejuvenation. Its primary aim is to eliminate accumulated toxins from the body, balance the doshas, and restore the body's natural harmony. This review explores the scientific evidence and clinical applications of Panchakarma therapies, focusing on their detoxification efficacy and therapeutic potential. Current studies suggest that Panchakarma interventions, such as Vamana (therapeutic vomiting), Virechana (purgation), Basti (medicated enema), Nasya (nasal administration of medicated oils), and Raktamokshana (bloodletting), provide substantial benefits in treating various chronic conditions, including metabolic disorders, autoimmune diseases, and stress-related ailments. Although several clinical trials and case studies support the positive impact of these therapies on overall health, their scientific validation remains limited. The primary objective of this review is to summarize the existing research on Panchakarma therapies and critically analyze their potential in detoxification and disease management. This paper also addresses gaps in the current literature and suggests areas for future research to further elucidate the mechanistic pathways and long-term benefits of Panchakarma treatments in modern healthcare systems. The findings of this review highlight the necessity of integrating Ayurvedic treatments into contemporary medical practices, offering a holistic approach to health and wellness.